A 6 up to "Autobahnkreuz Mannheim", exit "Mannheim-Mitte" towards A 656. Straight ahead in direction "Zentrum". This road is already the Augustaanlage. After 400 m on the right hand side you will see the hotel.
From direction Speyer, Worms, Bad Dürkheim:
A 650 direction Mannheim. This road goes over to the B 37, after that over the railway bridge (Konrad-Adenauer-Brücke), direction "Hauptbahnhof". Take a left at the main train station towards the "CCm Rosengarten". Take a right at the watertower, direction Highway, INTO the "Augustaanlage", by about 500 m you will see the hotel on the left hand side.